个人简介

肖浩，物理学博士，湖南师范大学第二类人才。2023年6月博士毕业于湖南师范大学物理与电子科学学院。2023年6月至2025年8月在湖南师范大学从事博士后科研工作。2025年9月入职湖南师范大学物理与电子科学学院。主要研究方向为冷冻电镜病毒结构解析及其功能应用。在国际权威杂志Nature Communications、PLoS Biology、PNAS、Protein & Cell等期刊发表学术论文20余篇，相关成果被Nature、Cell、PNAS、Science Advances、Nat Commun等期刊广泛引用。主持国家自然科学基金青年项目1项，湖南省自然科学基金青年项目1项，参与多项国家及省部级重大课题。获湖南省优秀博士学位论文、湖南师范大学优秀博士学位论文。担任Nat Commun、Commun Biol等期刊审稿人。

办公室：量子楼205

联系邮箱：xiaohao@hunnu.edu.cn

研究方向

软物质与生物物理；冷冻电镜病毒结构与功能研究

承担课题

1.国家自然科学基金青年项目：冷冻电镜噬菌体前衣壳非对称结构解析及组装机制研究（批准号：32401014），主持，在研。

2.湖南省自然科学基金青年项目：冷冻电镜沙门氏菌病毒P22非对称重构及组装机制研究（批准号：2024JJ6304），主持，在研。

3.湖南师范大学人才引进启动项目，项目负责人。

4.国家自然科学基金重点项目：冷冻电镜病毒非对称重构研究（批准号：12034006）,参与，在研。

5.湖南省发展与改革委员会项目：湖南师范大学软物质与生物物理平台建设（批准号：2507-430000-04-05-666048），参与，在研。

6.湖南省重大基础研究项目：病毒原子结构及其量子力学精度的动力学研究（批准号：2025ZYJ004），参与，在研。

7.湖南省自然科学基金创新群体项目：显微成像理论及生物应用（批准号：2019JJ10002），参与，结题。

8.国家自然科学基金面上项目：冷冻电镜噬菌体对称失配重构研究（批准号：32071209），参与，结题。

代表性论文

1.Yuning Peng, Hao Pang, Jing Zheng, Junquan Zhou, Wenyuan Chen, Fan Yang*,Hao Xiao*, and Hongrong Liu*. Structure of a Brochothrix thermosphacta bacteriophage reveals cell wall adsorption mechanism in Gram-positive infecting siphophages.Nature Communications. 2026, in press.

2.Hao Xiao#, Wenyuan Chen#, Hao Pang, Jing Zheng, Li Wang, Hao Feng, Jingdong Song*, Lingpeng Cheng*, Hongrong Liu*. Structure of the scaffolding protein and portal within the bacteriophage P22 procapsid provides insights into the self-assembly process.PLoS Biology. 2025, 23(4): e3003104.

3.Hao Xiao#, Le Tan#, Tan Zhixue#, Yewei Zhang, Wenyuan Chen, Xiaowu Li, Song Jingdong*, Lingpeng Cheng*, Hongrong Liu*. Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly.PLoS Biology. 2023,21(12): e3002441.

4.Wenyuan Chen#,Hao Xiao#, Wang Li#, Wang Xurong, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Song Jingdong*, Hongrong Liu*, Lingpeng Cheng*. Structural changes in bacteriophage T7 upon receptor-induced genome ejection.PNAS. 2021,118(37): e2102003118.

5.Wenyuan Chen#, Hao Xiao#, Wang Xurong, Song Shuanglin, Zhen Han, Xiaowu Li, Fan Yang, Wang Li, Song Jingdong, Hongrong Liu, Lingpeng Cheng. Structural changes of a bacteriophage upon DNA packaging and maturation.Protein Cell. 2020, 11(5):374-379.

6.Hao Xiao, Hao Pang, Junquan Zhou, Hao Feng, Jingdong Song, Lingpeng Cheng, Li Wang, Hongrong Liu*. Structural insights into minor and core proteins of bovine adenovirus 3: bridging capsid and genomic core.J Mol Biol.2025, 437(17):169208.

7.Hao Xiao, Zhou Junquan, Fan Yang, Zheng Liu, Song Jingdong, Wenyuan Chen*, Hongrong Liu*, Lingpeng Cheng*. Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures.Viruses. 2023,15(2):355.

8.Zheng Jing#,Hao Xiao#, Pang Hao, Wang Li, Song Jingdong, Wenyuan Chen, Lingpeng Cheng*, Hongrong Liu*. Conformational changes in and translocation of small proteins: insights into the ejection mechanism of podophages.J Virol. 2025, 99: e0124924.

9.Zhen Han, Wanjuan Yuan,Hao Xiao, Wang Li, Zhang Junxia, Yuning Peng, Lingpeng Cheng*, Hongrong Liu*, Li Huang*. Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail.PNAS. 2022, 119(31): e2119439119.

10.Jing Zheng#, Yuan Chen#, Siting Chen, Junquan Zhou,Hao Xiao, Fan Yang*, and Hongrong Liu*. Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection. PLOS Pathogens. 2026, in press.

11.Binning Sun#, Jing Zheng#, Yuan Fu, Fengyuan Tian,Hao Xiao, Su Li, Lingpeng Cheng, Ping Chen*, and Hongrong Liu*, Cryo-EM structure of drug-resistant Escherichia coli phage E1004 reveals a conserved cylindrical core among podophages,Structure. 2025, doi: 10.1016/j.str.2025.11.006.

12.Jing Zheng, Hao Pang,Hao Xiao, Junquan Zhou, Zhonghua Liu, Wenyuan Chen, Hongrong Liu. Asymmetric structure of podophage N4 from the Schitoviridae family reveals a type of tube-sheath short-tail architecture. Structure. 2025, 33(7):1250-1262.e2.

13.Zhou Junquan, Wang Liwen,Hao Xiao, Wenyuan Chen, Zhonghua Liu, Song Jingdong, Zheng Jing, Hongrong Liu. In situ structures of the contractile nanomachine myophage Mu in both its extended and contracted states. J Virol. 2025, 99(3): e0205624.

14.Yuan Chen, Hao Xiao, Junquan Zhou, Zeng Peng, Yuning Peng, Jingdong Song, Jing Zheng, Hongrong Liu*. The In Situ Structure of T-Series T1 Reveals a Conserved Lambda-Like Tail Tip.Viruses. 2025, 17(3):351.

15.Pang Hao, Fan Fenxia, Zheng Jing,Hao Xiao, Zhixue Tan, Song Jingdong*, Kan Biao*, Hongrong Liu*. Three-dimensional structures of Vibrio cholerae typing podophage VP1 in two states.Structure. 2024, 32(12):2364-2374.e2.

16.Yuning Peng, Tang Huanrong,Hao Xiao, Wenyuan Chen, Song Jingdong, Zheng Jing, Hongrong Liu. Structures of Mature and Urea-Treated Empty Bacteriophage T5: Insights into Siphophage Infection and DNA Ejection. Int J Mol Sci. 2024, 25(15):8479.

17.Xiao Chi, Xiaoyu Xia, Shunhao Xu, Qilin Huang,Hao Xiao, Song Jingdong. Automatic SARS-CoV-2 segmentation in electron microscopy based on few-shot learning. INT J WAVELETS MULTI. 2024, 22:2350047.

18.Zheng Jing, Wenyuan Chen, Hao Xiao, Fan Yang, Song Jingdong, Lingpeng Cheng*, Hongrong Liu*. Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers. J Mol Biol. 2023, 435(20):168258

19.Xiao Chi, Jun Wang, Shenrong Yang, Minxin Heng, Su Junyi,Hao Xiao, Song Jingdong, Weifu Li. VISN: virus instance segmentation network for TEM images using deep attention transformer.Brief Bioinform. 2023, 24(6): bbad373.

20.Fan Yang, Wang Liwen, Zhou Junquan,Hao Xiao, Hongrong Liu. In Situ Structures of the Ultra-Long Extended and Contracted Tail of Myoviridae Phage P1.Viruses. 2023, 15(6):1267.

21.Zheng Jing, Wenyuan Chen, Hao Xiao, Fan Yang, Xiaowu Li, Song Jingdong, Lingpeng Cheng, Hongrong Liu. A Capsid Structure of Ralstonia solanacearum podoviridae GP4 with a Triangulation Number T = 9.Viruses. 2022, 14(11):2431.

22.Xiao Chi, Chen Xi, Qiwei Xie, Li Guoqing,Hao Xiao, Song Jingdong, Han Hua. Virus identification in electron microscopy images by residual mixed attention network.Comput Methods Programs Biomed. 2021, 198:105766.

23.冯红丽,肖浩,岳成,宋敬东. 一种用于超薄切片样本的定位包埋板设计与应用.中国卫生检验杂志. 2021, 31(19):2312-2314,2320.

24.冯红丽,肖浩,于海斌,侯文哲,宋敬东,洪涛. 微波辅助超薄切片快速染色技术的优化与应用. 中华实验和临床病毒学杂志. 2020, 34(5):556-561.